Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are ligand-activated
transcription factors that regulate the expression of drug metabolizing enzymes and drug …

Preclinical evaluation of drug candidates in experimental animal models is an essential step
in drug development. Humanized mouse models have emerged as a promising alternative …

Because of their large surface area and conductivity, some inorganic materials have
emerged as good candidates for the trace-level detection of pharmaceutical drugs. In the …

This perspective discusses the role of pregnane xenobiotic receptor (PXR) in drug discovery
and the impact of its activation on CYP3A4 induction. The use of structural biology to reduce …

Tyrosine kinase inhibitors (TKI) are small heterocyclic molecules targeting transmembrane
and cytoplasmic tyrosine kinases that have met with considerable success in clinical …

Abstract Cytochrome P450 3A4 (CYP 3A4) is quantitatively the most important P450 enzyme
in adults. It is suggested that CYP 3A4 genetic polymorphisms may influence the rate of the …

Gilteritinib, an FDA-approved tyrosine kinase inhibitor approved for the treatment of
relapsed/refractory FLT3-mutated acute myeloid leukemia, is primarily eliminated via …

Deriving from targeted kinase inhibitors (TKIs), targeted covalent kinase inhibitors (TCKIs)
are a new class of TKIs that are covalently bound to their target residue of kinase receptors …

Backgrounds. Chaihu‐Shugan‐San (CSS) is a classic traditional Chinese herbal
prescription for treating depression. However, the underlying mechanism of the Chinese …

Many drugs that serve as first-line medications for the treatment of depression are
associated with severe side effects, including liver injury. Of the 34 antidepressants …