Choriocapillaris: fundamentals and advancements

R Lejoyeux, J Benillouche, J Ong, MH Errera… - Progress in Retinal and …, 2022 - Elsevier
The choriocapillaris is the innermost structure of the choroid that directly nourishes the
retinal pigment epithelium and photoreceptors. This article provides an overview of its …

Delivery systems in ocular retinopathies: the promising future of intravitreal hydrogels as sustained-release scaffolds

D Rafael, M Guerrero, A Marican, D Arango… - Pharmaceutics, 2023 - mdpi.com
Slow-release delivery systems are needed to ensure long-term sustained treatments for
retinal diseases such as age-related macular degeneration and diabetic retinopathy, which …

Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris

S An, H Yu, MDM Islam, X Zhang, Y Zhan, JJ Olivieri… - Scientific Reports, 2023 - nature.com
Evidence from histopathology and clinical imaging suggest that choroidal anatomy and
hemodynamic perfusion are among the earliest changes in retinal diseases such as age …

Form, shape and function: segmented blood flow in the choriocapillaris

MA Zouache, I Eames, CA Klettner, PJ Luthert - Scientific reports, 2016 - nature.com
The development of fluid transport systems was a key event in the evolution of animals and
plants. While within vertebrates branched geometries predominate, the choriocapillaris …

Patterns of choriocapillaris flow signal voids in central serous chorioretinopathy: an optical coherence tomography angiography study

A Matet, A Daruich, S Hardy, F Behar-Cohen - Retina, 2019 - journals.lww.com
Purpose: To investigate choriocapillaris flow signal void distribution on optical coherence
tomography (OCT) angiography in central serous chorioretinopathy (CSCR) and its …

Light color efficiency-balanced trans-palpebral illumination for widefield fundus photography of the retina and choroid

T Son, J Ma, D Toslak, A Rossi, H Kim, RVP Chan… - Scientific Reports, 2022 - nature.com
A wide-field fundus camera, which can selectively evaluate the retina and choroid, is
desirable for better detection and treatment evaluation of eye diseases. Trans-palpebral …

Variability in retinal neuron populations and associated variations in mass transport systems of the retina in health and aging

MA Zouache - Frontiers in aging neuroscience, 2022 - frontiersin.org
Aging is associated with a broad range of visual impairments that can have dramatic
consequences on the quality of life of those impacted. These changes are driven by a …

Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10

MA Zouache, A Bennion, JL Hageman, C Pappas… - Scientific reports, 2020 - nature.com
The two most common genetic contributors to age-related macular degeneration (AMD), a
leading cause of irreversible vision loss worldwide, are variants associated with CFH …

A revised hemodynamic theory of age-related macular degeneration

BD Gelfand, J Ambati - Trends in molecular medicine, 2016 - cell.com
Age-related macular degeneration (AMD) afflicts one out of every 40 individuals worldwide,
causing irreversible central blindness in millions. The transformation of various tissue layers …

Advancing treatment of retinal disease through in silico trials

RJ Hernandez, PA Roberts… - Progress in Biomedical …, 2023 - iopscience.iop.org
Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …