The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …

The role of epistasis in the genetic architecture of quantitative traits is controversial, despite
the biological plausibility that nonlinear molecular interactions underpin the genotype …

The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …

Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …

Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …

Genetic interactions identify combinations of genetic variants that impinge on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-
gene pairs for synthetic genetic interactions, generating quantitative genetic interaction …