The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects

A Minagar, MH Barnett, RHB Benedict, D Pelletier… - Neurology, 2013 - AAN Enterprises
The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle
that play major roles in cortical activation, relaying sensory information to the higher cortical …

Iron in multiple sclerosis: roles in neurodegeneration and repair

E Stephenson, N Nathoo, Y Mahjoub, JF Dunn… - Nature Reviews …, 2014 - nature.com
MRI and histological studies have shown global alterations in iron levels in the brains of
patients with multiple sclerosis (MS), including increases in the iron stored by macrophages …

Deep gray matter volume loss drives disability worsening in multiple sclerosis

A Eshaghi, F Prados, WJ Brownlee… - Annals of …, 2018 - Wiley Online Library
Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …

Thalamic atrophy in multiple sclerosis: a magnetic resonance imaging marker of neurodegeneration throughout disease

CJ Azevedo, SY Cen, S Khadka, S Liu… - Annals of …, 2018 - Wiley Online Library
Objective Thalamic volume is a candidate magnetic resonance imaging (MRI)‐based
marker associated with neurodegeneration to hasten development of neuroprotective …

Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis

MM Schoonheim, HE Hulst, RB Brandt, M Strik… - Neurology, 2015 - AAN Enterprises
Objective: This study investigates whether changes in functional connectivity, diffusivity, and
volume of the thalamus can explain different severities of cognitive impairment in multiple …

Quantitative susceptibility mapping for investigating subtle susceptibility variations in the human brain

F Schweser, K Sommer, A Deistung, JR Reichenbach - Neuroimage, 2012 - Elsevier
Quantitative susceptibility mapping (QSM) is a novel magnetic resonance-based technique
that determines tissue magnetic susceptibility from measurements of the magnetic field …

Early CNS neurodegeneration in radiologically isolated syndrome

CJ Azevedo, E Overton, S Khadka… - Neuroimmunology & …, 2015 - AAN Enterprises
Objective: Increasing evidence indicates that the thalamus may be a location of early
neurodegeneration in multiple sclerosis (MS). Our objective was to identify the presence of …

Magnetic resonance imaging in multiple sclerosis

CC Hemond, R Bakshi - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Since its technical development in the early 1980s, magnetic resonance imaging (MRI) has
quickly been adopted as an essential tool in supporting the diagnosis, longitudinal …

An illustrated comparison of processing methods for MR phase imaging and QSM: combining array coil signals and phase unwrapping

SD Robinson, K Bredies, D Khabipova… - NMR in …, 2017 - Wiley Online Library
Phase imaging benefits from strong susceptibility effects at very high field and the high
signal‐to‐noise ratio (SNR) afforded by multi‐channel coils. Combining the information from …

Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study

C Jacobsen, J Hagemeier, KM Myhr… - Journal of Neurology …, 2014 - jnnp.bmj.com
Objectives To identify MRI biomarkers associated with long-term disability progression in
patients with multiple sclerosis (MS), and to define the rate of evolution of global, tissue …