CRISPR screens have empowered the high-throughput dissection of gene functions;
however, more explicit genetic elements, such as codons of amino acids, require thorough …

Immune therapies targeting the PD-1/PD-L1 pathway have been employed in the treatment
of breast cancer, which requires aerobic glycolysis to sustain breast cancer cells growth …

Background: Atherosclerosis is a chronic inflammatory disease, in which macrophages
determine the progression of atherosclerotic plaques. However, no studies have …

ABSTRACT RB1CC1/FIP200 is an essential macroautophagy/autophagy protein that plays
an important role in a variety of biological and disease processes through its canonical …

Melanoma is a rare but highly lethal type of skin cancer whose incidence is increasing
globally. Melanoma is characterized by high resistance to therapy and relapse. Despite …

The V600E mutation in BRAF is associated with increased phosphorylation of Erk1/2 and
high sensitivity to BRAFi/MEKi combination in metastatic melanoma. In very few patients, a …

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive and heterogeneous biliary cancer
with a poor prognosis and limited treatment options. The molecular pathogenesis of iCCA …

This study delineated the elucidate molecular changes and their post-translational
modifications (PTMs) in heterogenetic colorectal cancer (CRC) for a deeper understanding …

Cellular responses leading to development, proliferation, and differentiation depend on
RAF/MEK/ERK signaling, which integrates and amplifies signals from various stimuli for …

Avian pathogenic E. coli (APEC), one of the widespread zoonotic-pathogen, can cause a
series of diseases collectively known as colibacillosis. This disease can cause thousands of …