Impaired brain glucose metabolism is considered a hallmark of brain dysfunction and
neurodegeneration. Disruption of the hexosamine biosynthetic pathway (HBP) and …

Protein O-GlcNAcylation is an abundant post-translational modification of intracellular
proteins with the monosaccharide N-acetylglucosamine covalently tethered to serines and …

The sodium channel Na v 1.7 is a master regulator of nociceptive input into the central
nervous system. Mutations in this channel can result in painful conditions and produce …

Pyroptosis is considered one of a critical factor in the recovery of neurological function
following traumatic brain injury. Brain injury activates a molecular signaling cascade …

O-GlcNAcylation is a reversible co-/post-translational modification involved in a multitude of
cellular processes. The addition and removal of the O-GlcNAc modification is controlled by …

Collapsin response mediator proteins (CRMPs) are ubiquitously expressed in neurons from
worms to humans. A cardinal feature of CRMPs is to mediate growth cone collapse in …

The modification of serine and threonine amino acids of proteins by O-linked N-
acetylglucosamine (O-GlcNAc) regulates the activity, stability, function, and subcellular …

Ion channels serve pleiotropic functions. Often found in complexes, their activities and
functions are sculpted by auxiliary proteins. We discovered that collapsin response mediator …

Despite continual efforts being made with multiple clinical studies and deploying cutting-
edge diagnostic tools and technologies, the discovery of new cancer therapies remains of …

O‐GlcNAc is a common post‐translational modification of nuclear, mitochondrial, and
cytoplasmic proteins that regulates normal physiology and the cell stress response …