The limb anatomy displays well‐defined dorsal and ventral compartments, housing
extensor, and flexor muscles, which play a crucial role in facilitating limb locomotion and …

One of the enduring debates in regeneration biology is the degree to which regeneration
mirrors development. Recent technical advances, such as single-cell transcriptomics and …

Following amputation, zebrafish regenerate their injured caudal fin through lineage-
restricted reprogramming. Although previous studies have charted various genetic and …

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with
both established leaders in the field and those earlier in their careers to discuss how the …

The ectoderm is the outermost of the three germ layers of the early embryo that arise during
gastrulation. Once the germ layers are established, the complex interplay of cellular …

Digit tip regeneration rebuilds amputated structures in some mammals if the nail organ is
preserved. In recently published Cell Reports papers, Castilla-Ibeas et al., Johnson et al …

In the mouse distal terminal phalanx (P3), it remains unclear why amputation at less than
33% of the digit results in regeneration, while amputation exceeding 67% leads to non …

Appendage regeneration varies drastically across vertebrate species. Some species, such
as urodele amphibians, are capable of complete limb regeneration, however mammals have …

Although many species are capable of regenerating damaged tissues, the mammalian
response to injury is limited to fibrosis and scarring. Activated fibroblasts are primarily …

The mammalian (including human) digit tip is the only region in the limb capable of
regenerating after an amputation, a phenomenon associated with the presence of the nail …