Glutamate receptor ion channels mediate excitatory responses at the majority of CNS
synapses. They are the only ligand-gated ion channels for which multiple high-resolution …

Ampakines are drugs structurally derived from aniracetam that potentiate currents mediated
by AMPA type glutamate receptors. These drugs slow deactivation and attenuate …

Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA,
kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor …

Glutamate is the predominant excitatory neurotransmitter in the central nervous system. The
receptors that bind glutamate, including N-methyl-d-aspartate (NMDA) and α-amino-3 …

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-type glutamate receptors
mediate fast excitatory transmission throughout the central nervous system. Positive …

Stargazin is an accessory protein of AMPA receptors that enhances surface expression and
also affects the biophysical properties of the receptor. AMPA receptor domains necessary for …

AMPA receptors consist of a family of hetero‐oligomeric (tetrameric) receptors arising from
four genes, each of which encodes a distinct receptor subunit (GluA1‐4). Recombinant …

This paper summarizes the present knowledge on how positive allosteric modulators
(PAMs) interact with the ligand‐binding domain (LBD) of AMPA and kainate receptors …

Previous studies of the lurcher mutation in GluR1 channels concluded that its main effect is
to create constitutively active channels (;). GluR1Lc channels also exhibit slowed kinetics …

A series of AMPA receptor positive allosteric modulators has been optimized from poorly
penetrant leads to identify molecules with excellent preclinical pharmacokinetics and CNS …