TAM family kinases as therapeutic targets at the interface of cancer and immunity

D DeRyckere, JM Huelse, HS Earp… - Nature Reviews Clinical …, 2023 - nature.com
Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

AXL inhibitors: status of clinical development

S Bhalla, DE Gerber - Current oncology reports, 2023 - Springer
Abstract Purpose of Review The AXL signaling pathway is associated with tumor growth as
well as poor prognosis in cancer. Here, we highlight recent strategies for targeting AXL in …

Two-front war on cancer—Targeting TAM receptors in solid tumour therapy

A Mikolajczyk, F Mitula, D Popiel, B Kaminska… - Cancers, 2022 - mdpi.com
Simple Summary In recent years, many studies have shown the importance of TAM kinases
in both normal and neoplastic cells. In this review, we present and discuss the role of the …

Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders

V Gadiyar, G Patel, J Chen, D Vigil, N Ji… - Frontiers in …, 2023 - frontiersin.org
TAM receptors (TYRO3, AXL, and MERTK) comprise a family of homologous receptor
tyrosine kinases (RTK) that are expressed across a range of liquid and solid tumors where …

Histopathological scoring system role in evaluation of electronic cigarette's impact on respiratory pathway in albino rat: Biochemical, histo-morphometric and …

NH Hassan, DI El-Wafaey - Tissue and Cell, 2022 - Elsevier
Background Electronic cigarettes have gained growing popularity especially among
adolescents and young adults. Although the dominant consideration by consumers and the …