Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy

J Pan, L Zhou, C Zhang, Q Xu, Y Sun - Signal transduction and targeted …, 2022 - nature.com
Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

[HTML][HTML] Mitogen activated protein kinase (MAPK) activation, p53, and autophagy inhibition characterize the severe acute respiratory syndrome coronavirus 2 (SARS …

AM Kyriakopoulos, G Nigh, PA McCullough, S Seneff - Cureus, 2022 - ncbi.nlm.nih.gov
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and
prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions …

Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection

NS Sharif-Askari, FS Sharif-Askari, B Mdkhana… - Free Radical Biology …, 2021 - Elsevier
Severe viral infections, including SARS-COV-2, could trigger disruption of the balance
between pro-oxidant and antioxidant mediators; the magnitude of which could reflect the …

Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons

C Di Primio, P Quaranta, M Mignanelli, G Siano… - PNAS …, 2023 - academic.oup.com
COVID-19 has represented an issue for global health since its outbreak in March 2020. It is
now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Theophylline: Old drug in a new light, application in COVID-19 through computational studies

LM Montaño, B Sommer, JC Gomez-Verjan… - International Journal of …, 2022 - mdpi.com
Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory
diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 …

Inflammatory pathways in COVID‐19: mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

Interleukin-17, a salivary biomarker for COVID-19 severity

FS Sharif-Askari, NS Sharif-Askari, S Hafezi… - PloS one, 2022 - journals.plos.org
Objectives T-helper 17 cell-mediated response and their effector IL-17 cytokine induced by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a major cause …

SARS-CoV-2 infection alters mitochondrial and cytoskeletal function in human respiratory epithelial cells mediated by expression of spike protein

BH Yeung-Luk, GA Narayanan, B Ghosh, A Wally… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2, SCV2), which has resulted in higher morbidity and …

[HTML][HTML] An integrated in-silico Pharmaco-BioInformatics approaches to identify synergistic effects of COVID-19 to HIV patients

MA Hossain, MH Rahman, H Sultana, A Ahsan… - Computers in Biology …, 2023 - Elsevier
Background With high inflammatory states from both COVID-19 and HIV conditions further
result in complications. The ongoing confrontation between these two viral infections can be …

How aging and oxidative stress influence the cytopathic and inflammatory effects of SARS-CoV-2 infection: The role of cellular glutathione and cysteine metabolism

F Galli, G Marcantonini, D Giustarini, MC Albertini… - Antioxidants, 2022 - mdpi.com
SARS-CoV-2 infection can cause a severe respiratory distress syndrome with inflammatory
and thrombotic complications, the severity of which increases with patients' age and …