The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

In the present report, we extend previous findings in the 5XFAD mouse model and
demonstrate that these mice develop an age-dependent motor phenotype in addition to …

Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
today. The search for new treatments is made ever more urgent by prospects for increasing …

Progression of brain ageing is influenced by a complex interaction of genetic and
environmental factors. Analysis of genetically modified animals with uniform genetic …

Animal models aim to replicate the symptoms, the lesions or the cause (s) of Alzheimer
disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its …

Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is
also composed of neuropsychiatric symptoms including psychological distress and …

Alzheimer's disease (AD) is one of the most common causes of dementia. Its pathogenesis
is characterized by the aggregation of the amyloid-β (Aβ) protein in senile plaques and the …

Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that
differ from those observed in normal aging. Transgenic models of AD are a promising tool in …

BACKGROUND: In aging mice, activity maintains hippocampal plasticity and adult
hippocampal neurogenesis at a level corresponding to a younger age. Here we studied …