With each trajectory taken during the ontogeny of an individual, the number of optional
behavioural phenotypes that can be expressed across its life span is reduced. The initial …

With many caveats to the traditional vertebrate species pertaining to biogerontology
investigations, it has been suggested that a most informative model is the one which: 1) …

Abstract The National Institute on Aging's Interventions Testing Program was established to
evaluate agents that are purported to increase lifespan and delay the appearance of age …

Abstract RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in
several types of cancers, however, their contribution to liver disease is unknown. Here we …

Wnt/β‐catenin signaling is a primary pathway for stem cell maintenance during tissue
renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis …

CDKL5 deficiency disorder (CDD) is an infantile, epileptic encephalopathy presenting with
early-onset seizures, intellectual disability, motor impairment, and autistic features. The …

Serum anti-Müllerian hormone (AMH) is a biomarker for predicting antral follicle counts but
there is no clear consensus on whether AMH is indicative of primordial follicle counts in …

Pedomorphy, maintenance of juvenile traits throughout life, is most pronounced in
extraordinarily long-lived naked mole-rats. Many of these traits (eg, slow growth rates, low …

Glutathione (GSH) is the most abundant intracellular thiol and an important regulator of
cellular redox status. Mice that lack the modifier subunit of glutamate cysteine ligase (Gclm) …

Although characterization of the baseline oral microbiota has been discussed, the current
literature seems insufficient to draw a definitive conclusion on the interactions between the …