T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

There is a long-standing assumption that naive CD4+ and CD8+ T cells are largely
homogeneous populations despite the extraordinary diversity of their T cell receptors (TCR) …

Abstract Cytotoxic-T-lymphocyte (CTL) mediated control of HIV-1 is enhanced by targeting
highly networked epitopes in complex with human-leukocyte-antigen-class-I (HLA-I) …

T cell activation is a critical event in the adaptive immune response, indispensable for cell-
mediated and humoral immunity as well as for immune regulation. Recent years have …

T cell receptors (TCR) on cytolytic T lymphocytes (CTLs) recognize" foreign" antigens bound
in the groove of major histocompatibility complex (MHC) molecules (H-2 in mouse and HLA …

Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs
in the thymus,,–. Signalling through the pre-T cell receptor (preTCR), a CD3-associated …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease that
arises from the oncogenic transformation of developing T cells during T-lymphopoiesis …

αβ T cells are critical components of the adaptive immune system and are capable of
inducing sterilizing immunity after pathogen infection and eliminating transformed tumor …

Expression of the pre-T cell receptor (preTCR) is an important checkpoint during the
development of T cells, an essential cell type of our adaptive immune system. The preTCR …

Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and
activation of T cells. Quantitative aspects of TCR signaling have an important role during …