The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that
mediates a broad spectrum of (patho) physiological processes in response to numerous …

Thermophilic actinomycetes produce enzymes capable of hydrolyzing synthetic polyesters
such as polyethylene terephthalate (PET). In addition to carboxylesterases, which have …

How phospholipids are trafficked between the bacterial inner and outer membranes through
the hydrophilic space of the periplasm is not known. We report that members of the …

Higher eukaryotic chromosomes are organized into topologically constrained functional
domains; however, the molecular mechanisms required to sustain these complex interphase …

In order to survive, bacteria continually sense, and respond to, environmental fluctuations.
Stringent control represents a key bacterial stress response to nutrient starvation, that leads …

The conidia of airborne fungi are protected by a hydrophobic protein layer that coats the cell
wall polysaccharides and renders the spores resistant to wetting and desiccation. A similar …

Nicotinamide adenine dinucleotide (NAD+) has emerged as a key component in prokaryotic
and eukaryotic immune systems. The recent discovery that Toll/interleukin-1 receptor (TIR) …

Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling
pathways, often in creative ways. CE clan proteases, specific hydrolases for ubiquitin-like …

Abstract Treatment with β-lactam antibiotics, particularly cephalosporins, is a major risk
factor for Clostridioides difficile infection. These broad-spectrum antibiotics irreversibly …

The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been
known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to …