A model for RAS mutation patterns in cancers: finding the sweet spot
S Li, A Balmain, CM Counter - Nature Reviews Cancer, 2018 - nature.com
The three RAS genes—HRAS, NRAS and KRAS—are collectively mutated in one-third of
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …
Clonal hematopoiesis and associated diseases: A review of recent findings
S Asada, T Kitamura - Cancer science, 2021 - Wiley Online Library
Recent genome‐wide studies have revealed that aging or chronic inflammation can cause
clonal expansion of cells in normal tissues. Clonal hematopoiesis has been the most …
clonal expansion of cells in normal tissues. Clonal hematopoiesis has been the most …
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
M Meisel, R Hinterleitner, A Pacis, L Chen, ZM Earley… - Nature, 2018 - nature.com
Somatic mutations in te t methylcytosine dioxygenase 2 (TET2), which encodes an
epigenetic modifier enzyme, drive the development of haematopoietic malignancies,,,,,–. In …
epigenetic modifier enzyme, drive the development of haematopoietic malignancies,,,,,–. In …
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia
Transposable elements or transposons are major players in genetic variability and genome
evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) …
evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) …
Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display …
silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display …
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis
RM Carr, D Vorobyev, T Lasho, DL Marks… - Nature …, 2021 - nature.com
Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is
associated with dismal outcomes. RAS pathway mutations, mainly NRAS G12D, define the …
associated with dismal outcomes. RAS pathway mutations, mainly NRAS G12D, define the …
Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care
H Döhner, A Dolnik, L Tang, JF Seymour, MD Minden… - Leukemia, 2018 - nature.com
Older patients with newly diagnosed acute myeloid leukemia (AML) in the phase 3 AZA-AML-
001 study were evaluated at entry for cytogenetic abnormalities, and a subgroup of patients …
001 study were evaluated at entry for cytogenetic abnormalities, and a subgroup of patients …
Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management
MM Patnaik, A Tefferi - American journal of hematology, 2018 - Wiley Online Library
Disease overview Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic
stem cell disorder with overlapping features of myelodysplastic syndromes and …
stem cell disorder with overlapping features of myelodysplastic syndromes and …
Chronic Myelomonocytic leukemia: 2020 update on diagnosis, risk stratification and management
MM Patnaik, A Tefferi - American journal of hematology, 2020 - Wiley Online Library
Disease overview Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic
stem cell disorder with overlapping features of myelodysplastic syndromes and …
stem cell disorder with overlapping features of myelodysplastic syndromes and …
Driver mutations in acute myeloid leukemia
A Kishtagari, RL Levine, AD Viny - Current opinion in hematology, 2020 - journals.lww.com
Driver mutations in acute myeloid leukemia : Current Opinion in Hematology Driver mutations
in acute myeloid leukemia : Current Opinion in Hematology Log in or Register Subscribe to …
in acute myeloid leukemia : Current Opinion in Hematology Log in or Register Subscribe to …