Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens

JL Hicks, KEA Oldham, J McGarvie… - Bioscience …, 2022 - portlandpress.com
Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic
resistance is one the biggest threats to global health and food security. Identifying new and …

Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis

AD Potter, AK Criss - Emerging Topics in Life Sciences, 2023 - portlandpress.com
Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea,
is a human-adapted pathogen that does not productively infect other organisms. The …

A plasmid-free Zymomonas mobilis mutant strain reducing reactive oxygen species for efficient bioethanol production using industrial effluent of xylose mother liquor

B Geng, S Liu, Y Chen, Y Wu, Y Wang… - … in Bioengineering and …, 2022 - frontiersin.org
Genome minimization is an effective way for industrial chassis development. In this study,
Zymomonas mobilis ZMNP, a plasmid-free mutant strain of Z. mobilis ZM4 with four native …

Spatiotemporal dynamics of bacterial taxonomic and functional profiles in estuarine intertidal soils of China coastal zone

Z Zhang, P Han, Y Zheng, S Jiao, H Dong, X Liang… - Microbial ecology, 2023 - Springer
Bacteria play an important role in regulating carbon (C), nitrogen (N), and sulfur (S) in
estuarine intertidal wetlands. To gain insights into the ecological and metabolic modes …

A CysB regulator positively regulates cysteine synthesis, expression of type III secretion system genes, and pathogenicity in Ralstonia solanacearum

M Chen, W Zhang, L Han, X Ru, Y Cao… - Molecular Plant …, 2022 - Wiley Online Library
A syringe‐like type III secretion system (T3SS) plays essential roles in the pathogenicity of
Ralstonia solanacearum, which is a causal agent of bacterial wilt disease on many plant …

Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as sources of essential cysteine

JC Berude, P Kennouche, ML Reniere… - Infection and …, 2024 - Am Soc Microbiol
Listeria monocytogenes (Lm) is a Gram-positive facultative intracellular pathogen that leads
a biphasic lifecycle, transitioning its metabolism and selectively inducing virulence genes …

Sulfate depletion triggers overproduction of phospholipids and the release of outer membrane vesicles by Neisseria meningitidis

MJH Gerritzen, DE Martens, JP Uittenbogaard… - Scientific Reports, 2019 - nature.com
Outer membrane vesicles (OMVs) produced by bacteria are interesting vaccine candidates.
OMVs are nanoparticles that contain many immunogenic components, are self-adjuvating …

Proteomic Analyses of Acinetobacter baumannii Clinical Isolates to Identify Drug Resistant Mechanism

P Wang, RQ Li, L Wang, WT Yang, QH Zou… - Frontiers in cellular and …, 2021 - frontiersin.org
Acinetobacter baumannii is one of the main causes of nosocomial infections. Increasing
numbers of multidrug-resistant Acinetobacter baumannii cases have been reported in recent …

Optimal protein allocation controls the inhibition of GltA and AcnB in Neisseria gonorrhoeae

N Shahreen, NB Chowdhury, R Saha - Pathogens and Disease, 2024 - academic.oup.com
Neisseria gonorrhea (Ngo) is a major concern for global public health due to its severe
implications for reproductive health. Understanding its metabolic phenotype is crucial for …

Targeting the cysteine biosynthesis pathway: Mechanism, structure, and drug discovery

Y Tao, D Zheng, W Zou, T Guo, G Liao… - European Journal of …, 2024 - Elsevier
Owing to the global health crisis of resistant pathogenic infections, researchers are
emphasizing the importance of novel prevention and control strategies. Existing …