Advancing pathogen genomics in resource-limited settings

PM Pronyk, R de Alwis, R Rockett, K Basile… - Cell Genomics, 2023 - cell.com
Genomic sequencing has emerged as a powerful tool to enhance early pathogen detection
and characterization with implications for public health and clinical decision making …

Prevalence of fever of unidentified aetiology in East African adolescents and adults: a systematic review and meta-analysis

F Nooh, A Chernet, K Reither, J Okuma… - Infectious Diseases of …, 2023 - Springer
Background Primary health care settings and hospitals of low-and middle-income countries
have few accessible diagnostic tools and limited laboratory and human resources capacity …

Blazing the trail for innovative tuberculosis diagnostics

S Yerlikaya, T Broger, C Isaacs, D Bell, L Holtgrewe… - Infection, 2024 - Springer
The COVID-19 pandemic brought diagnostics into the spotlight in an unprecedented way not
only for case management but also for population health, surveillance, and monitoring. The …

Overcoming colonialism in pathogen genomics

S Saha, Y Hooda, GN Malavige, MI Nisar - The Lancet Digital Health, 2024 - thelancet.com
Historical legacies of colonialism affect the distribution and control of scientific knowledge
today, including within the pathogen genomics field, which remains dominated by high …

Threat Agnostic Epidemiology and Surveillance in US Public Health Agencies: Future Potential and Needs

AM Adams, J Arrazola, ER Daly, M Tompkins - Health security, 2024 - liebertpub.com
As the frontline of the US public health system, applied epidemiologists at state, tribal, local,
and territorial health agencies play a critical role in biodefense and ensuring the nation's …

[HTML][HTML] Incorporating direct molecular diagnostics in management algorithms for nontuberculous mycobacteria: Is it high time?

CJ Opperman, S Singh, W Goosen, H Cox, R Warren… - IJID regions, 2024 - Elsevier
Nontuberculous mycobacteria (NTM) are a group of acid-fast mycobacteria other than
Mycobacterium tuberculosis complex (MTBC) that cause pulmonary disease that is similar to …

宏基因组高通量测序技术的临床应用: 现状, 挑战与前景

刁振丽, 李金明 - 协和医学杂志, 2023 - xhyxzz.pumch.cn
传统微生物学检测方法难以满足临床复杂多变的病原体检测需求. 近年来,
新兴的宏基因组高通量测序(metagenomic next-generation sequencing, mNGS) …

CZ ID: a cloud-based, no-code platform enabling advanced long read metagenomic analysis

SE Simmonds, L Ly, R Lim, T Morse, SG Thakku… - bioRxiv, 2024 - biorxiv.org
Metagenomics has enabled the rapid, unbiased detection of microbes across diverse
sample types, leading to exciting discoveries in infectious disease, microbiome, and viral …

The Translational Potential of Next-Generation Sequencing and Biological Mass Spectrometry in Patients with Central Nervous System Infections in Vietnam.

MN Nghiem - 2024 - oro.open.ac.uk
Central nervous system (CNS) infections cause significant mortality and morbidity
worldwide. Novel diagnostic approaches are therefore urgently needed to improve patient …

AlignDx: Enabling Automated, Cloud-Based Workflows for Streamlined Bioinformatic-Focused Pathogen Surveillance

M Hunjan - 2023 - uwspace.uwaterloo.ca
The rising trends in infectious disease burden, alongside the recent COVID-19 pandemic,
underline the need for effective public health disease mitigation strategies like pathogen …