Calcium is the major regulator of keratinocyte differentiation in vivo and in vitro. A calcium
gradient within the epidermis promotes the sequential differentiation of keratinocytes as they …

Calcium has an established role in the normal homeostasis of mammalian skin and serves
as a modulator in keratinocyte proliferation and differentiation. Gradients of calcium …

During melanoma development, loss of functional E-cadherin accompanies gain of
expression of N-cadherin. The present study was carried out to investigate the functional …

Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue
homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are …

P-cadherin is a classical cell-to-cell adhesion molecule with a homeostatic function in
several normal tissues. However, its behaviour in the malignant setting is notably dependent …

Various adhesion molecules have been implicated in T lymphocyte binding to dermal
vascular endothelium in psoriasis vulgaris, but the chemotactic signals that promote …

Purpose: It has been proposed that melanoma cells shift from E-cadherin to N-cadherin
expression during tumor development, and recent gene profiling has shown increased …

BACKGROUND Gastric cancer remains a major cause of cancer mortality globally but no
good prognostic tumour marker is available. Soluble fragment of E-cadherin protein has …

E-cadherin is known to be an important molecule in epithelial–mesenchymal transition
(EMT). Malignant transformation of melanocytes frequently attends with loss of E-cadherin …

Extracellular Ca 2+(Ca 2+ o) is a critical regulator that promotes differentiation in epidermal
keratinocytes. The calcium sensing receptor (CaR) is essential for mediating Ca 2+ …