Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several
neurodegenerative tauopathies including Alzheimer's disease (AD) and some …

Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …

Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by
insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased …

Tau pathogenesis is a hallmark of many neurodegenerative diseases, including Alzheimer's
disease (AD). Although the events leading to initial tau misfolding and subsequent tau …

Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary
tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau …

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder
characterized by the loss of motor neurons. Fused in sarcoma/translated in liposarcoma …

Tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are
histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated …

Many neurodegenerative diseases are characterized by deficiencies in neuronal axonal
transport, a process in which cellular cargo is shuttled with the aid of molecular motors from …

Accumulation of tau protein is a key pathology of age-related neurodegenerative diseases
such as Alzheimer's disease and progressive supranuclear palsy. Those diseases are …