The structural elucidation of small molecules using mass spectrometry plays an important
role in modern life sciences and bioanalytical approaches. This review covers different soft …

Post-translational modifications of proteins control many biological processes, and
examining their diversity is critical for understanding mechanisms of cell regulation. Mass …

Gene expression is a multistep process that involves the transcription, translation and
turnover of messenger RNAs and proteins. Although it is one of the most fundamental …

A novel, MS‐based approach for the relative quantification of proteins, relying on the
derivatization of primary amino groups in intact proteins using isobaric tag for relative and …

Stable isotope labeling by amino acids in cell culture (SILAC) has become a versatile tool for
quantitative, mass spectrometry (MS)-based proteomics. Here, we completely label mice …

The turnover of each protein in the mammalian proteome is a functionally important
characteristic. Here, we employed high-resolution mass spectrometry to quantify protein …

Biological function and cellular responses to environmental perturbations are regulated by a
complex interplay of DNA, RNA, proteins and metabolites inside cells. To understand these …

Mass spectrometry (MS)-based proteomics is increasingly applied in a quantitative format,
often based on labeling of samples with stable isotopes that are introduced chemically or …

An important area of proteomics involves the need for quantification, whether relative or
absolute. Many methods now exist for relative quantification, but to support biomarker …

There is a saying,“Eyes are the windows to the soul”. In much the same vein, blood, since it
flows through the entire body, can be considered the window to the physical condition of the …