MicroRNAs (miRNAs) are a class of small non-coding RNAs that post-transcriptionally
regulate the expression of approximately 50% of all protein-coding genes. They have been …

The p53 tumor suppressor is embedded in a large gene network controlling diverse cellular
and organismal phenotypes. Multiple signaling pathways converge onto p53 activation …

Reversible protein modification by small ubiquitin-like modifiers (SUMOs) is critical for
eukaryotic life. Mass spectrometry-based proteomics has proven effective at identifying …

Methylation of lysine 4 on histone H3 (H3K4) at promoters is tightly linked to transcriptional
regulation in human cells. At least six different COMPASS-like multisubunit (SET1/MLL) …

The human POK family members are transcription factors with a POZ domain and zinc-
fingers that act primarily as transcriptional repressors. Several members of this family are …

The transcriptional network regulating antibody-secreting cell (ASC) differentiation has been
extensively studied, but our current understanding is limited. The mechanisms of action of …

An increasing body of evidence indicates that miR-149 can both suppress and promote
tumor growth depending on the tumor type. However, the role of miR-149 in the progression …

MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene
expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are …

FOXP transcription factors play important roles in neurodevelopment, but little is known
about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate …

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown etiology and
is considered to be an autoimmune disease. Autoantibodies are important tools for accurate …