Down syndrome: Neurobiological alterations and therapeutic targets
Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …
[PDF][PDF] Oxidative stress and Down syndrome. Do antioxidants play a role in therapy?
J Muchová, I Zitnanova… - Physiological …, 2014 - pdfs.semanticscholar.org
Oxidative stress is a phenomenon associated with imbalance between production of free
radicals and reactive metabolites (eg superoxide and hydrogen peroxide) and the …
radicals and reactive metabolites (eg superoxide and hydrogen peroxide) and the …
Systematic review and meta-analysis shows a specific micronutrient profile in people with Down Syndrome: Lower blood calcium, selenium and zinc, higher red blood …
A Saghazadeh, M Mahmoudi, A Dehghani Ashkezari… - PloS one, 2017 - journals.plos.org
Different metabolic profiles as well as comorbidities are common in people with Down
Syndrome (DS). Therefore it is relevant to know whether micronutrient levels in people with …
Syndrome (DS). Therefore it is relevant to know whether micronutrient levels in people with …
Down syndrome and the enteric nervous system
SW Moore - Pediatric surgery international, 2008 - Springer
Down syndrome (DS) is the most common chromosomal abnormality occurring in humans.
Up to 77% of DS children have associated gastrointestinal (GI) abnormalities, which may be …
Up to 77% of DS children have associated gastrointestinal (GI) abnormalities, which may be …
[HTML][HTML] Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study
A Gimeno, JL García-Giménez, L Audí, N Toran… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Down Syndrome is the most common chromosomal disease and is also known for its
decreased incidence of solid tumors and its progeroid phenotype. Cellular and systemic …
decreased incidence of solid tumors and its progeroid phenotype. Cellular and systemic …
Oxidative stress and cognitive ability in adults with Down syndrome
AIMS: We aimed to study the hypothesis that high levels of superoxide dismutase (SOD1),
previously reported in Down syndrome, would be associated with poorer ability on cognitive …
previously reported in Down syndrome, would be associated with poorer ability on cognitive …
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
DC Cabelof, HV Patel, Q Chen… - Blood, The Journal …, 2009 - ashpublications.org
Down syndrome (DS) children have a unique genetic susceptibility to develop leukemia, in
particular, acute megakaryocytic leukemia (AMkL) associated with somatic GATA1 …
particular, acute megakaryocytic leukemia (AMkL) associated with somatic GATA1 …
Advances in understanding the association between Down syndrome and Hirschsprung disease (DS–HSCR)
SW Moore - Pediatric Surgery International, 2018 - Springer
The clinical association between Trisomy 21 (Down syndrome) and aganglionosis
(Hirschsprung disease; DS–HSCR) is well-established, being of the order of 5% and …
(Hirschsprung disease; DS–HSCR) is well-established, being of the order of 5% and …
Reduced salivary flow rate and high levels of oxidative stress in whole saliva of children with Down syndrome
NB Domingues, MR Mariusso… - Special Care in …, 2017 - Wiley Online Library
Aim To investigate salivary parameters between children with Down Syndrome (DS) and
without DS. Materials and Methods Stimulated whole saliva was collected from 18 children …
without DS. Materials and Methods Stimulated whole saliva was collected from 18 children …
Erythrocyte phospholipid molecular species and fatty acids of Down syndrome children compared with non-affected siblings
AA Bueno, A Brand, MM Neville, C Lehane… - British Journal of …, 2015 - cambridge.org
The majority of children with Down syndrome (DS) develop Alzheimer's disease (AD) at an
early age. Although long-chain n-3 fatty acids (FA) are protective of neurodegeneration, little …
early age. Although long-chain n-3 fatty acids (FA) are protective of neurodegeneration, little …