GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
Benzodiazepines in Alzheimer's disease: beneficial or detrimental effects
Dementia is considered a clinical syndrome characterized by cognitive dysfunction and
memory loss. Alzheimer's disease (AD) is the most common type of dementia. AD is linked …
memory loss. Alzheimer's disease (AD) is the most common type of dementia. AD is linked …
Insights on benzodiazepines' potential in Alzheimer's disease
Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …
Benzodiazepines and related drugs as a risk factor in Alzheimer's disease dementia
M Ettcheto, J Olloquequi, E Sanchez-Lopez… - Frontiers in aging …, 2020 - frontiersin.org
Benzodiazepines (BZDs) and Z-drugs are compounds widely prescribed in medical practice
due to their anxiolytic, hypnotic, and muscle relaxant properties. Yet, their chronic use is …
due to their anxiolytic, hypnotic, and muscle relaxant properties. Yet, their chronic use is …
The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex
J Ethiraj, TH Palpagama, C Turner, B van der Werf… - Scientific reports, 2021 - nature.com
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous
system. The GABA signaling system in the brain is comprised of GABA synthesizing …
system. The GABA signaling system in the brain is comprised of GABA synthesizing …
MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABAA receptors in aged mice
W Zuo, J Zhao, J Zhang, Z Fang, J Deng, Z Fan… - Journal of …, 2021 - Springer
Background Perioperative neurocognitive disorder (PND) is a long-term postoperative
complication in elderly surgical patients. The underlying mechanism of PND is unclear, and …
complication in elderly surgical patients. The underlying mechanism of PND is unclear, and …
Association between Z drugs use and risk of cognitive impairment in middle-aged and older patients with chronic insomnia
F Guo, L Yi, W Zhang, ZJ Bian… - Frontiers in Human …, 2021 - frontiersin.org
Background: Benzodiazepines (BZDs) and Non-BZDs (NBZDs) have been widely used for
patients with chronic insomnia. Long-term uses of BZDs may cause cognitive impairment …
patients with chronic insomnia. Long-term uses of BZDs may cause cognitive impairment …
Activity-and sleep-dependent regulation of tonic inhibition by Shisa7
Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A receptors (GABA A
Rs) critically regulates neuronal excitability and brain function. However, the mechanisms …
Rs) critically regulates neuronal excitability and brain function. However, the mechanisms …
The excitatory-inhibitory balance as a target for the development of novel drugs to treat schizophrenia
The intricate balance between excitation and inhibition (E/I) in the brain plays a crucial role
in normative information processing. Dysfunctions in the E/I balance have been implicated in …
in normative information processing. Dysfunctions in the E/I balance have been implicated in …
Epigenetics in prader-willi syndrome
AJP Mendiola, JM LaSalle - Frontiers in Genetics, 2021 - frontiersin.org
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder that affects
approximately 1 in 20,000 individuals worldwide. Symptom progression in PWS is …
approximately 1 in 20,000 individuals worldwide. Symptom progression in PWS is …