Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

Liquid biopsy is a diagnostic repeatable test, which in last years has emerged as a powerful
tool for profiling cancer genomes in real-time with minimal invasiveness and tailoring …

Tumours are often composed of a multitude of malignant clones that are genomically
unique, and only a few of them may have the ability to escape cancer therapy and grow as …

It is increasingly appreciated that cancer cell heterogeneity and plasticity constitute major
barriers to effective clinical treatments and long-term therapeutic efficacy. Research in the …

The pattern of delayed recurrence in a subset of breast cancer patients has long been
explained by a model that incorporates a variable period of cellular or tumor mass dormancy …

There is increasing evidence that the spatial organization of cells within the tumor-immune
microenvironment (TiME) of solid tumors influences survival and response to therapy in …

During tumor evolution, cancer cells can acquire the ability to proliferate, invade neighboring
tissues, evade the immune system, and spread systemically. Tracking this process remains …

Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To
understand how malignant clones survive and grow in metastatic niches, in vivo models …

Genomic DNA barcoding has emerged as a sensitive and flexible tool to measure the fates
of clonal subpopulations within a heterogeneous cancer cell population. Coupling cellular …

Massively parallel sequencing technologies have long been used in both basic research
and clinical routine. The recent introduction of digital sequencing has made previously …