Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free
visualization and analysis of functional, endogenous biomolecules in living systems. When …

Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy
metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives …

Confocal Raman spectral imaging (RSI) enables high-content, label-free visualization of a
wide range of molecules in biological specimens without sample preparation. However …

The vibrational modes of molecules provide an intrinsic contrast mechanism for identifying
components in cells, tissues, and organisms. When excited by a laser, Raman scattered …

We report in this study an intrinsic link between pyrimidine metabolism and liver lipid
accumulation utilizing a uridine phosphorylase 1 transgenic mouse model UPase1-TG …

Predominant evidence of non-alcoholic fatty liver disease (NAFLD) is the accumulation of
excess lipids in the liver. A small group with NAFLD may have a more serious condition …

Background High fat or fructose induces non-alcoholic fatty liver disease (NAFLD)
accompanied of mitochondrial dysfunction and oxidative stress. Controversy remains about …

Uridine is a pyrimidine nucleoside that exerts restorative functions in tissues under stress.
Short-term co-administration of uridine with multiple unrelated drugs prevents drug-induced …

Nonalcoholic fatty liver disease (NAFLD) prevalence is increasing worldwide, with the
affected US population estimated near 30%. Diet is a recognized risk factor in the NAFLD …

Raman spectroscopy has shown very promising results in medical diagnostics by providing
label-free and highly specific molecular information of pathological tissue ex vivo and in …