The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

The development of spatial transcriptomics (ST) technologies has transformed genetic
research from a single-cell data level to a two-dimensional spatial coordinate system and …

Spatial transcriptomic and proteomic technologies have provided new opportunities to
investigate cells in their native microenvironment. Here we present Giotto, a comprehensive …

A major feature of cancer is the heterogeneity, both intratumoral and intertumoral. Traditional
single-cell techniques have given us a comprehensive understanding of the biological …

Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …

Maps of the nervous system inspire experiments and theories in neuroscience. Advances in
molecular biology over the past decades have revolutionized the definition of cell and tissue …

Simple Summary Prostate cancer is a heterogenous disease in terms of disease
aggressiveness and therapy response, leading to dilemmas in treatment decisions. This …

Spatially resolved transcriptomics (SrT) can investigate organ or tissue architecture from the
angle of gene programs that define their molecular complexity. However, computational …

Spatial transcriptomic is a technology to provide deep transcriptomic profiling by preserving
the spatial organization. Here, we present a framework for SPAtial Transcriptomic Analysis …

The molecular mechanisms underlying lethal castration-resistant prostate cancer remain
poorly understood, with intratumoral heterogeneity a likely contributing factor. To examine …