Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …

Abstract Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here
we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid …

Islets of Langerhans are fundamental in understanding diabetes. A healthy human pancreas
from a donor has been used to asses various islet parameters and their three-dimensional …

Background Amyloid-related degenerative diseases are associated with the accumulation of
misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid …

OBJECTIVE—Little is known about the capacity, mechanisms, or timing of growth in β-cell
mass in humans. We sought to establish if the predominant expansion of β-cell mass in …

The pathological sequence for type 2 diabetes is complex and entails many different
elements that act in concert to cause that disease. This review proposes a sequence of …

Amyloid deposition and reduced β-cell mass are pathological hallmarks of the pancreatic
islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with …

Abstract Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet …

It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …