The e rythropoietin-p roducing h epatocellular carcinoma (Eph) receptor tyrosine kinase
family plays important roles in developmental processes, adult tissue homeostasis, and …

Chronic pain is a debilitating condition that influences the social, economic, and
psychological aspects of patients' lives. Hence, the need for better treatment is drawing …

Although largely confined to the airways, SARS-CoV-2 infection has been associated with
sensory abnormalities that manifest in both acute and chronic phenotypes. To gain insight …

Aims Sustained visceral hypersensitivity is a hallmark of irritable bowel syndrome (IBS)
could be partially explained by enteric neural remodeling. Particularly, synaptic plasticity in …

Persistent, in particular neuropathic pain affects millions of people worldwide. However, the
response rate of patients to existing analgesic drugs is less than 50%. There are several …

Multiple cellular components are involved in the complex pathological process following
central nervous system (CNS) injury, including neurons, glial cells and endothelial cells …

Chronic pain is a frequent and disabling condition that is significantly maintained by central
sensitization, which results in pathological amplification of responses to noxious and …

Patients with irritable bowel syndrome (IBS) show pain hypersensitivity and smooth muscle
hypercontractility in response to colorectal distension (CRD). Synaptic plasticity, a key …

Alzheimer's disease (AD) is devastating and leads to permanent losses of memory and other
cognitive functions. Although recent genetic evidences strongly argue for a causative role of …

Previous studies have demonstrated that the synaptic EphB1 receptor tyrosine kinase is a
major mediator of neuropathic pain, suggesting that targeting the activity of this receptor …