Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics

A Ajoolabady, S Wang, G Kroemer… - Pharmacology & …, 2021 - Elsevier
Stroke constitutes the second leading cause of death and a major cause of disability
worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) …

Zebrafish as a potential model for neurodegenerative diseases: a focus on toxic metals implications

E Paduraru, D Iacob, V Rarinca, G Plavan… - International Journal of …, 2023 - mdpi.com
In the last century, industrial activities increased and caused multiple health problems for
humans and animals. At this moment, heavy metals are considered the most harmful …

Cellular and molecular mechanisms mediating methylmercury neurotoxicity and neuroinflammation

JP Novo, B Martins, RS Raposo, FC Pereira… - International journal of …, 2021 - mdpi.com
Methylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir,
MeHg bioaccumulates along the food chain until it is consumed by riverine populations …

Bisphenol F-induced neurotoxicity toward zebrafish embryos

L Yuan, L Qian, Y Qian, J Liu, K Yang… - Environmental …, 2019 - ACS Publications
In this study, the influence of bisphenol F (BPF) toward central nervous system (CNS) was
assessed using zebrafish embryos. We found that BPF could induce significant neurotoxicity …

The toxicity of mercury and its chemical compounds: molecular mechanisms and environmental and human health implications: a comprehensive review

YS Wu, AI Osman, M Hosny, AM Elgarahy… - Acs Omega, 2024 - ACS Publications
Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the
environment and human health. This review is aimed at discussing the state-of-the-art …

TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway

H Wu, G Chen, J Wang, M Deng, F Yuan… - Cell …, 2020 - Wiley Online Library
Objectives T‐cell immunoglobulin domain and mucin domain‐4 (TIM‐4) is selectively
expressed on antigen‐presenting cells (APCs) and modulates various immune responses …

Bisphenol S impairs behaviors through disturbing endoplasmic reticulum function and reducing lipid levels in the brain of zebrafish

W Wang, Z Li, X Zhang, J Zhang… - Environmental Science & …, 2022 - ACS Publications
The number of neurotoxic pollutants is increasing, but their mechanism of action is unclear.
Here, zebrafish were exposed to 0, 1, 10, and 100 μg/L bisphenol S (BPS) for different …

Cr (VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway

SC Fu, JM Liu, KI Lee, FC Tang, KM Fang, CY Yang… - Toxicology in Vitro, 2020 - Elsevier
Abstract Hexavalent chromium (Cr (VI)), a well-known toxic industrial and environmental
pollutant, has been shown to cause serious toxic and health effects. However, limited …

Regulation of endoplasmic reticulum stress-autophagy: a potential therapeutic target for ulcerative colitis

D Qiao, Z Zhang, Y Zhang, Q Chen, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa
and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic …

How autophagy, a potential therapeutic target, regulates intestinal inflammation

SL Chen, CM Li, W Li, QS Liu, SY Hu, MY Zhao… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation in
the intestines, with the primary types including ulcerative colitis and Crohn's disease. The …