RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

Introduction Venetoclax (VEN), a selective BCL2 inhibitor, has single‐agent activity in
relapsed and refractory (R/R) acute myeloid leukemia (AML), and efficacy in lower intensity …

This phase 1b trial (NCT02670044) evaluated venetoclax-idasanutlin in patients with
relapsed/refractory (R/R) acute myeloid leukemia (AML) ineligible for cytotoxic …

Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which
is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs …

Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and
clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes …

Acute myeloid leukemia (AML) with t (8; 21)(q22; q22. 1); RUNX1-RUNX1T1, one of the core-
binding factor leukemias, is one of the most common subtypes of AML with recurrent genetic …

Nucleophosmin (NPM1) is among the most frequently mutated genes in acute myeloid
leukemia (AML). It is not known, however, how the resulting oncoprotein mutant NPM1 is …

Hematologic malignancies represent the fourth most frequently diagnosed cancer in
economically developed countries. In hematologic malignancies normal hematopoiesis is …

Colorectal cancer liver metastasis (CRCLM) has two major histopathological growth
patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement …