Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require
adhesion and transmigration through blood-vessel walls. The traditional three steps of …

Cancer immunotherapy modulates immune cells to induce antitumor immune responses.
Tumors employ immune checkpoints to evade immune cell attacks. Immune checkpoint …

Despite the fundamental roles of sialyl-and fucosyltransferases in mammalian physiology,
there are few pharmacological tools to manipulate their function in a cellular setting …

In inflammation, neutrophils and other leukocytes roll along the microvascular endothelium
before arresting and transmigrating into inflamed tissues. Arrest requires conformational …

The selectins and their ligands are required for leukocyte extravasation during inflammation.
Several glycoproteins have been suggested to bind to E-selectin in vitro, but the complete …

Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …

Integrins are transmembrane proteins that mediate cellular adhesion and migration to
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …

Engagement of neutrophils by E-selectin results in integrin activation. Here, we investigated
primary mouse neutrophils in whole blood by using intravital microscopy and autoperfused …

Platelet activation is known to be associated with the release of a vast array of chemokines
and proinflammatory lipids which induce pleiotropic effects on a wide variety of tissues and …