First contact: the role of respiratory cilia in host-pathogen interactions in the airways

LE Kuek, RJ Lee - … Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

Therapeutic potential of ectopic olfactory and taste receptors

SJ Lee, I Depoortere, H Hatt - Nature Reviews Drug Discovery, 2019 - nature.com
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …

Flavonoids: structure–function and mechanisms of action and opportunities for drug development

S Safe, A Jayaraman, RS Chapkin, M Howard… - Toxicological …, 2021 - Springer
Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and
dietary consumption of these structurally diverse compounds is associated with multiple …

A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors

L Li, X Yan, F Chen, L Zheng, Y Hu, F He… - … Reviews in Food …, 2023 - Wiley Online Library
Citrus is an important source of flavonoids in our daily diet. Citrus flavonoids have
antioxidant, anticancer, anti‐inflammatory, and cardiovascular disease prevention functions …

Clinical role of extraoral bitter taste receptors

J Jeruzal-Świątecka, W Fendler… - International Journal of …, 2020 - mdpi.com
Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty
substances are linked to ion channels, while sweet, bitter and umami flavours are …

Bitter taste receptor T2R14 detects quorum sensing molecules from cariogenic Streptococcus mutans and mediates innate immune responses in gingival epithelial …

MR Medapati, N Singh, AY Bhagirath… - The FASEB …, 2021 - Wiley Online Library
Host‐pathogen interactions play an important role in defining the outcome of a disease.
Recent studies have shown that the bacterial quorum sensing molecules (QSM) can interact …

Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells

RJ Lee, BM Hariri, DB McMahon, B Chen… - Science …, 2017 - science.org
In the upper respiratory epithelium, bitter and sweet taste receptors present in solitary
chemosensory cells influence antimicrobial innate immune defense responses. Whereas …

Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling

JR Freund, CJ Mansfield, LJ Doghramji… - Journal of Biological …, 2018 - ASBMB
Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

Taste receptors in upper airway innate immunity

RM Carey, RJ Lee - Nutrients, 2019 - mdpi.com
Taste receptors, first identified on the tongue, are best known for their role in guiding our
dietary preferences. The expression of taste receptors for umami, sweet, and bitter have …

Loss of CFTR function is associated with reduced bitter taste receptor-stimulated nitric oxide innate immune responses in nasal epithelial cells and macrophages

RM Carey, JN Palmer, ND Adappa, RJ Lee - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …