The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Ferroptosis is a recently recognized cell death modality that is morphologically,
biochemically and genetically distinct from other forms of cell death and that has emerged to …

Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-
associated macrophages (TAMs) enhance the aerobic glycolysis and apoptotic resistance of …

Metastasis—the disseminated growth of tumours in distant organs—underlies cancer
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …

Amino acid transporters mediate substrates across cellular membranes and their fine-tuned
regulations are critical to cellular metabolism, growth, and death. As the functional …

Metabolic pathways must be adapted to support cell processes required for transformation
and cancer progression. Amino acid metabolism is deregulated in many cancers, with …