Solvation parameter model: Tutorial on its application to separation systems for neutral compounds

CF Poole - Journal of Chromatography A, 2021 - Elsevier
The solvation parameter model affords a useful tool to model distribution properties of
neutral compounds in biphasic separation systems. Common applications include column …

Influence of solvent effects on retention of small molecules in reversed-phase liquid chromatography

CF Poole - Chromatographia, 2019 - Springer
Major obstacles to formulating a simple retention mechanism for reversed-phase liquid
chromatography are identified as the heterogeneous composition of the stationary phase …

Analysis of the solvent strength parameter (linear solvent strength model) for isocratic separations in reversed-phase liquid chromatography

CF Poole, SN Atapattu - Journal of Chromatography A, 2022 - Elsevier
The solvent strength parameter (slope) and intercept (log kw) of the linear solvent strength
model are determined for methanol-water (17 columns), acetonitrile-water (15 columns) …

Determination of physicochemical properties of small molecules by reversed-phase liquid chromatography

CF Poole, SN Atapattu - Journal of Chromatography a, 2020 - Elsevier
The physicochemical properties of small molecules that can be determined by retention
measurements in reversed-phase liquid chromatography include solvent-based properties …

Selectivity evaluation of core-shell silica columns for reversed-phase liquid chromatography using the solvation parameter model

CF Poole, SN Atapattu - Journal of Chromatography A, 2020 - Elsevier
For the selectivity evaluation of core-shell silica, siloxane-bonded reversed-phase columns
by the solvation parameter model a minimal set of thirty-five calibration compounds were …

Reversed-phase liquid chromatography system constant database over an extended mobile phase composition range for 25 siloxane-bonded silica-based columns

CF Poole - Journal of Chromatography A, 2019 - Elsevier
The solvation parameter model is used to characterize the retention properties of 25
siloxane-bonded type-B silica columns under typical reversed-phase liquid chromatography …

Solvation properties of acetone-water mobile phases in reversed-phase liquid chromatography

SN Atapattu - Journal of Chromatography A, 2021 - Elsevier
The solvation parameter model is used for the selectivity evaluation of siloxane-bonded
reversed-phase columns with mobile phases containing from 20-70%(v/v) acetone-water …

Unique selectivity of tetrahydrofuran-2-propanol-water ternary mobile phases on a superficially porous particle column in reversed-phase liquid chromatography

SN Atapattu - Journal of Chromatography A, 2023 - Elsevier
Three mixed mobile phase organic modifiers, tetrahydrofuran: 2-propanol 1: 1 (v/v),
tetrahydrofuran: 2-propanol: 1: 3 (v/v), and tetrahydrofuran: 2-propanol: 3: 1 (v/v) were …

Selectivity comparison of acetonitrile‐methanol‐water ternary mobile phases on an octadecylsiloxane‐bonded silica stationary phase

SN Atapattu - Journal of Separation Science, 2023 - Wiley Online Library
The solvation parameter model was used in this study to investigate various intermolecular
interactions that influence retention on the standard C18 stationary phase for the solvent …

Chromatographic test methods for characterizing alkylsiloxane-bonded silica columns for reversed-phase liquid chromatography

CF Poole - Journal of Chromatography B, 2018 - Elsevier
Major obstacles to formulating a simple retention mechanism for reversed-phase liquid
chromatography have a direct impact on the development of experimental methods for …