Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

The systemic spread of tumor cells is the ultimate cause of the majority of deaths from
cancer, yet few successful therapeutic strategies have emerged to specifically target …

Cancer stem cells (CSCs) contribute to the initiation, recurrence, and metastasis of cancer;
however, there are still no drugs targeting CSCs in clinical application. There are several …

Rationale: Hepatocellular carcinoma (HCC) is an aggressive malignant solid tumor wherein
CDK1/PDK1/β-Catenin is activated, suggesting that inhibition of this pathway may have …

Evolutionarily conserved Notch plays a critical role in embryonic development and cellular
self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is …

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy with limited
treatment options for recurrent or metastatic disease. Due to chemotherapy resistance and …

The poor clinical outcome of hepatocellular carcinoma (HCC) patients is ascribed to the
resistance of HCC cells to traditional treatments and tumor recurrence after curative …

Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer.
Although there are different treatment options, these strategies are not efficient in terms of …