Transaminases (TAs) are one of the most promising biocatalysts in organic synthesis for the
preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity …

Chiral amines are important components of 40–45% of small molecule pharmaceuticals and
many other industrially important fine chemicals and agrochemicals. Recent advances in …

The use of transaminases to access pharmaceutically relevant chiral amines is an attractive
alternative to transition-metal-catalysed asymmetric chemical synthesis. However, one major …

During the last decade the use of ω‐transaminases has been identified as a very powerful
method for the preparation of optically pure amines from the corresponding ketones. Their …

Transaminases (TAms) are important enzymes for the production of chiral amines for the
pharmaceutical and fine chemical industries. Novel TAms for use in these industries have …

A new colorimetric method has been developed to screen transaminases using an
inexpensive amine donor. The assay is sensitive, has a low level of background coloration …

The present review focuses on a subfamily of pyridoxal phosphate (PLP)-dependent
enzymes, belonging to the broader fold-type I structural group and whose archetypes can be …

Abstract Pyridoxal-5′-phosphate-dependent transaminases of fold type IV (class IV) are
promising enzymes for (R)-selective amination of organic compounds. Transaminases of …

Non-canonical amino acids (ncAAs) have been utilized as an invaluable tool for modulating
the active site of the enzymes, probing the complex enzyme mechanisms, improving …

Abstract (R)-stereospecific amine transaminases (R-ATAs) are important biocatalysts for the
production of (R)-amine compounds in a strict stereospecific manner. An improved R-ATA …