Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor
prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have …
prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have …
The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas
Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and
neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most …
neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most …
Reduced-dose radiotherapy for human papillomavirus-associated squamous-cell carcinoma of the oropharynx: a single-arm, phase 2 study
AM Chen, C Felix, PC Wang, S Hsu, V Basehart… - The Lancet …, 2017 - thelancet.com
Background Head and neck cancers positive for human papillomavirus (HPV) are
exquisitely radiosensitive. We investigated whether chemoradiotherapy with reduced-dose …
exquisitely radiosensitive. We investigated whether chemoradiotherapy with reduced-dose …
Identification of the cell-intrinsic and-extrinsic pathways downstream of EGFR and IFNγ that induce PD-L1 expression in head and neck cancer
Many cancer types, including head and neck cancers (HNC), express programmed death
ligand 1 (PD-L1). Interaction between PD-L1 and its receptor, programmed death 1 (PD-1) …
ligand 1 (PD-L1). Interaction between PD-L1 and its receptor, programmed death 1 (PD-1) …
Enhanced radiation sensitivity in HPV-positive head and neck cancer
Patients with human papillomavirus (HPV+)–associated head and neck cancer (HNC) show
significantly improved survival outcome compared with those with HPV-negative (HPV−) …
significantly improved survival outcome compared with those with HPV-negative (HPV−) …
HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity
T Rieckmann, S Tribius, TJ Grob, F Meyer… - Radiotherapy and …, 2013 - Elsevier
BACKGROUND AND PURPOSE: When treated by radiotherapy, patients with squamous
cell carcinomas of the head and neck (HNSCC) positive for HPV and p16INK4a possess a …
cell carcinomas of the head and neck (HNSCC) positive for HPV and p16INK4a possess a …
The roles of glucose metabolic reprogramming in chemo-and radio-resistance
J Lin, L Xia, J Liang, Y Han, H Wang, L Oyang… - Journal of Experimental …, 2019 - Springer
Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The
aberrant glucose metabolism is associated with dramatically increased bioenergetics …
aberrant glucose metabolism is associated with dramatically increased bioenergetics …
Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma
S Partlová, J Bouček, K Kloudová, E Lukešová… - …, 2015 - Taylor & Francis
Human papillomavirus (HPV) infection is one of the most important etiologic causes of
oropharyngeal head and neck squamous cell carcinoma (HNSCC). Patients with HPV …
oropharyngeal head and neck squamous cell carcinoma (HNSCC). Patients with HPV …
Cisplatin alters antitumor immunity and synergizes with PD-1/PD-L1 inhibition in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) has been treated for decades with
cisplatin chemotherapy, and anti–PD-1 immunotherapy has recently been approved for the …
cisplatin chemotherapy, and anti–PD-1 immunotherapy has recently been approved for the …
The role of human papillomavirus in nongenital cancers
DP Zandberg, R Bhargava, S Badin… - CA: a cancer journal …, 2013 - Wiley Online Library
Answer questions and earn CME/CNE Human papillomavirus (HPV), one of the most
common sexually transmitted diseases worldwide, has an established role in the …
common sexually transmitted diseases worldwide, has an established role in the …