Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …

Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

Dendritic spines are tiny membrane specialization forming the postsynaptic part of most
excitatory synapses. They have been suggested to play a crucial role in regulating synaptic …

Alterations in inhibitory interneurons contribute to cognitive deficits associated with several
psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ …

Brain networks that engage the hippocampus and prefrontal cortex are central for enabling
effective interactions with our environment. Some of the cognitive processes that these …

Working memory functions supported by the prefrontal cortex decline in normal aging.
Disruption of corticolimbic GABAergic inhibitory circuits can impair working memory in young …

Summary Neuregulin 1 (Nrg1) is a susceptibility gene of schizophrenia, a disabling mental
illness that affects 1% of the general population. Here, we show that ctoNrg1 mice, which …

Hippocampal interneuron populations are reportedly vulnerable to normal aging. The
relationship between interneuron network integrity and age‐related memory impairment …

Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types
in affected brain regions. Despite this, transcriptomic analyses of the human brain have …

Aging-related changes in the brain have been mostly studied through the comparison of
young adult and very old animals. However, aging must be considered a lifelong process of …