Diagnosis, prognosis, and clinical management of mild traumatic brain injury

HS Levin, RR Diaz-Arrastia - The Lancet Neurology, 2015 - thelancet.com
Concussion and mild traumatic brain injury (TBI) are interchangeable terms to describe a
common disorder with substantial effects on public health. Advances in brain imaging, non …

The IDEAL framework for surgical robotics: development, comparative evaluation and long-term monitoring

HJ Marcus, PT Ramirez, DZ Khan, H Layard Horsfall… - Nature medicine, 2024 - nature.com
The next generation of surgical robotics is poised to disrupt healthcare systems worldwide,
requiring new frameworks for evaluation. However, evaluation during a surgical robot's …

Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic …

L Papa, GM Brophy, RD Welch, LM Lewis… - JAMA …, 2016 - jamanetwork.com
Importance Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-
L1) have been widely studied and show promise for clinical usefulness in suspected …

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system

BA Plog, ML Dashnaw, E Hitomi, W Peng… - Journal of …, 2015 - Soc Neuroscience
The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an
intense search for blood-based biomarkers that can objectively predict the severity of injury …

The future of blood-based biomarkers for Alzheimer's disease

K Henriksen, SE O'Bryant, H Hampel… - Alzheimer's & …, 2014 - Elsevier
Abstract Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of
easily accessible biomarkers that can detect disease presence and predict disease risk …

GFAP out-performs S100β in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with …

L Papa, S Silvestri, GM Brophy, P Giordano… - Journal of …, 2014 - liebertpub.com
Both glial fibrillary acidic protein (GFAP) and S100β are found in glial cells and are released
into serum following a traumatic brain injury (TBI), however, the clinical utility of S100β as a …

A review of microRNA biomarkers in traumatic brain injury

H Atif, SD Hicks - Journal of experimental neuroscience, 2019 - journals.sagepub.com
There is growing public concern surrounding traumatic brain injury (TBI). TBI can cause
significant morbidity, and the long-term sequelae are poorly understood. TBI diagnosis and …

Systematic review of clinical studies examining biomarkers of brain injury in athletes after sports-related concussion

L Papa, MM Ramia, D Edwards, BD Johnson… - Journal of …, 2015 - liebertpub.com
The aim of this study was to systematically review clinical studies examining biofluid
biomarkers of brain injury for concussion in athletes. Data sources included PubMed® …

[HTML][HTML] Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a …

L Papa, MR Zonfrillo, RD Welch, LM Lewis… - BMJ paediatrics …, 2019 - ncbi.nlm.nih.gov
Objectives To evaluate the ability of glial fibrillary acidic protein (GFAP) and ubiquitin C-
terminal hydrolase (UCH-L1) to detect concussion in children and adult trauma patients with …

The biomarker S100B and mild traumatic brain injury: a meta-analysis

C Oris, B Pereira, J Durif, J Simon-Pimmel… - …, 2018 - publications.aap.org
OBJECTIVE: A meta-analysis is conducted to assess the prognostic value of S100B in
predicting intracerebral lesions in children after mTBI. DATA SOURCES: Medline, Embase …