An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid
peroxidation. This process contributes to cellular and tissue damage in various human …
peroxidation. This process contributes to cellular and tissue damage in various human …
The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function
Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …
[HTML][HTML] PPARα inhibition overcomes tumor-derived exosomal lipid-induced dendritic cell dysfunction
X Yin, W Zeng, B Wu, L Wang, Z Wang, H Tian, L Wang… - Cell reports, 2020 - cell.com
Dendritic cells (DCs) orchestrate the initiation, programming, and regulation of anti-tumor
immune responses. Emerging evidence indicates that the tumor microenvironment (TME) …
immune responses. Emerging evidence indicates that the tumor microenvironment (TME) …
Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation
Fatty acid metabolism is essential for the biogenesis of cellular components and ATP
production to sustain proliferation of cancer cells. Long-chain fatty acyl-CoA synthetases …
production to sustain proliferation of cancer cells. Long-chain fatty acyl-CoA synthetases …
Fuel availability and fate in cardiac metabolism: A tale of two substrates
F Pascual, RA Coleman - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
The heart's extraordinary metabolic flexibility allows it to adapt to normal changes in
physiology in order to preserve its function. Alterations in the metabolic profile of the heart …
physiology in order to preserve its function. Alterations in the metabolic profile of the heart …
Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways
PA Young, CE Senkal, AL Suchanek… - Journal of Biological …, 2018 - ASBMB
Fatty acid channeling into oxidation or storage modes depends on physiological conditions
and hormonal signaling. However, the directionality of this channeling may also depend on …
and hormonal signaling. However, the directionality of this channeling may also depend on …
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation
Oxylipins are potent biological mediators requiring strict control, but how they are removed
en masse during infection and inflammation is unknown. Here we show that …
en masse during infection and inflammation is unknown. Here we show that …
Preservation of acyl coenzyme A attenuates pathological and metabolic cardiac remodeling through selective lipid trafficking
Background: Metabolic remodeling in heart failure contributes to dysfunctional lipid
trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty …
trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty …
Integrated metabolomics and lipidomics analyses reveal metabolic reprogramming in human glioma with IDH1 mutation
L Zhou, Z Wang, C Hu, C Zhang… - Journal of proteome …, 2018 - ACS Publications
Mutations in isocitrate dehydrogenase (IDH) 1 are high-frequency events in low-grade
glioma and secondary glioblastoma, and IDH1 mutant gliomas are vulnerable to …
glioma and secondary glioblastoma, and IDH1 mutant gliomas are vulnerable to …
Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids [S]
EL Klett, S Chen, A Yechoor, FB Lih… - Journal of lipid research, 2017 - ASBMB
Because the signaling eicosanoids, epoxyeicosatrienoic acids (EETs) and HETEs, are
esterified to membrane phospholipids, we asked which long-chain acyl-CoA synthetase …
esterified to membrane phospholipids, we asked which long-chain acyl-CoA synthetase …