Cisplatin-based chemotherapeutic regimens are the most frequently used (neo) adjuvant
treatments for the majority of solid tumors. While platinum-based chemotherapeutic …

Parkinson's disease (PD) is a multifactorial age-related movement disorder in which defects
of both mitochondria and the endoplasmic reticulum (ER) have been reported. The unfolded …

We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and
polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress …

Lipid accumulation is a central event in the development of chronic metabolic diseases,
including obesity and type 2 diabetes, but the mechanisms responsible for lipid …

Atmospheric pressure room temperature plasma jets (APRTP-Js) that can emit a mixture of
different active species have recently found entry in various medical applications. Apoptosis …

Background Recently, natural killer (NK) cells emerged as a treatment option for various
solid tumors. However, the immunosuppressive tumor immune microenvironment (TIME) …

Human High temperature requirement A2 (HtrA2) is a mitochondrial protease chaperone
that plays an important role in cellular proteostasis and in regulating cell-signaling events …

Several endpoints associated with cellular responses to DNA damage as well as overt
cytotoxicity were multiplexed into a miniaturized,“add and read” type flow cytometric assay …

Importance of the field: The HtrA family proteins are serine proteases that are involved in
important physiological processes, including maintenance of mitochondrial homeostasis …

We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric
analysis of detergent‐liberated nuclei that are simultaneously stained with propidium iodide …