Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable …

Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …

Immune rejection is an important obstacle to the use of allogeneic 'off-the-shelf'cells for
transplantation into immunocompetent patients. Genetic modification has emerged as a …

Parkinson disease (PD) is a neurological movement disorder resulting primarily from
damage to and degeneration of the nigrostriatal dopaminergic pathway. The pathway …

Neurodegenerative diseases are characterized by irreversible cell damage, loss of neuronal
cells and limited regeneration potential of the adult nervous system. Pluripotent stem cells …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, affecting 1%–2% of the population over the age of 65. As the …

Heart regeneration addresses a central problem in cardiology, the irreversibility of the loss of
myocardium that eventually leads to heart failure. True restoration of heart function can only …

Huntington's disease (HD) is a rare inherited neurodegenerative disease that manifests
mostly in adulthood with progressive cognitive, behavioral, and motor dysfunction. Neuronal …

The regenerative capacity of the heart has long fascinated scientists. In contrast to other
organs such as liver, skin, and skeletal muscle, the heart possesses only a minimal …

Abstract Purpose of Review Human pluripotent stem cells have the potential to revolutionize
the treatment of inborn and degenerative diseases, including aging and autoimmunity. A …