Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …

Abstract New fifteen 7-chloroquinolines (M1a-o) were synthesized by microwave irradiation
and conventional route via Schiff-base reaction. The key intermediate 4-((7-chloroquinolin-4 …

The drug resistance problem is most acute in the case of bacteria. There is always a need to
develop novel antibacterial drugs with better mechanisms of action. Most of the quinoline …

Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …

Malaria, one of the most striking, re‐emerging infectious diseases caused by the genus
Plasmodium, places a huge burden on global healthcare systems. A major challenge in the …

The tautomerizations mechanism of 4-(methylsulfanyl)-3 [(1Z)-1-(2-phenylhydrazinylidene)
ethyl] quinoline-2 (1H)-one were inspected in the gas phase and ethanol using density …

A series of 2-pyrazolyl quinolones has been designed and synthesized in 5–7 steps to
optimize for both in vitro antimalarial potency and various in vitro drug metabolism and …

The interesting pharmaceutical and biological activities of 4-hydroxy-2-quinolones make
them valuable in drug research and development. Hence, many publications have recently …

To develop novel antibacterial agents, 2-sulfoether-4-quinolone scaffolds were synthesized
by a free radical process and evaluated for their antibacterial abilities. Excellent activities …