Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …

Cancer cell mutations can be identified by genomic and transcriptomic techniques.
However, they are not sufficient to understand the full complexity of cancer heterogeneity …

Background Camptothecin (CPT) and its derivatives are currently used as second-or third-
line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert …

Malaria is among the major threats to global health with the main burden of disease being in
rural areas of developing countries where accurate diagnosis based on non-invasive …

Abstract Topoisomerase I (TOP1) regulates DNA topology during replication and
transcription whereas tyrosyl-DNA phosphodiesterase 1 (TDP1) is involved in the repair of …

Simple Summary Standard chemotherapy is still ineffective in metastatic colon cancer and
does not target cancer stem cells (CSCs). The combination of standard cytostatic drugs with …

The heterogeneity of tumor cells and the potential existence of rare cells with reduced
chemotherapeutic response is expected to play a pivotal role in the development of drug …

DNA topoisomerases (Top) are a group of isomerase enzymes responsible for controlling
the topological problems caused by DNA double helix in the cell during the processes of …

In the modern world with climate changes and increasing pollution, different types of stress
are becoming an increasing challenge. Hence, the identification of reliable biomarkers of …

Background: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-
cancer drugs. Parasites require topoisomerase 1 activity for survival and, consequently …