The development of rotavirus vaccines that are based on heterotypic or serotype-specific
immunity has prompted many countries to establish programs to assess the disease burden …

The development and implementation of safe and effective vaccines to prevent the
enormous health burden of rotavirus-associated disease is a global public health goal …

One hundred rotavirus strains detected in children with acute diarrhea in Blantyre, Malawi,
between July 1997 and January 1998 were characterized for G (VP7) and P (VP4) types by …

A non-enveloped virus requires a membrane lesion to deliver its genome into a target cell.
For rotaviruses, membrane perforation is a principal function of the viral outer-layer protein …

The morphogenesis of rotaviruses follows a unique pathway in which immature double-
layered particles (DLPs) assembled in the cytoplasm bud across the membrane of the …

ABSTRACT We characterized 1,534 rotavirus (RV) strains collected in Bangladesh from
1992 to 1997 to assess temporal changes in G type and to study the most common G and P …

Rotavirus infection seems to be a multistep process in which the viruses are required to
interact with several cell surface molecules to enter the cell. The virus spike protein VP4 …

A PCR typing assay was developed to identify rotavirus P types (VP4 specificity) of bovine
NCDV, UK, and B223 strains and porcine OSU and Gottfried strains. Thirty-nine human and …

This study describes an approach to the molecular typing of rotaviruses which requires only
a single RNA extraction and reverse transcription (RT) reaction using random primers …

Live oral rotavirus vaccines that are effective in middle and high income countries have
been much less immunogenic and effective among infants in resource-limited settings …