The growing field of immune metabolism has revealed promising indications for metabolic
targets to modulate anti-cancer immunity. Combination therapies involving metabolic …

Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

Mitochondria are important signalling organelles, and they dictate immunological fate. From
T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that …

Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer
effects; however, the underlying mechanism is poorly understood. Here we show that this …

Considerable efforts have been made since the 1950s to better understand the cellular and
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …

Interest in the topic of tumour metabolism has waxed and waned over the past century of
cancer research. The early observations of Warburg and his contemporaries established …

Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well
as certain diabetes risk factors and treatments. This consensus statement of experts …

Aging is characterized by a deterioration in the maintenance of homeostatic processes over
time, leading to functional decline and increased risk for disease and death. The aging …

Summary The National Institute on Aging Interventions Testing Program (ITP) evaluates
agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each …