Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
AKH Loe, L Zhu, TH Kim - Experimental & molecular medicine, 2023 - nature.com
Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a
multifactorial disease highly influenced by environmental factors, which include radiation …
multifactorial disease highly influenced by environmental factors, which include radiation …
Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer
Gastric cancer (GC) is the fifth most common cancer worldwide and is a heterogeneous
disease. Among GC subtypes, the mesenchymal phenotype (Mes-like) is more invasive than …
disease. Among GC subtypes, the mesenchymal phenotype (Mes-like) is more invasive than …
Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities
Background Epigenetic modifications, such as DNA methylation and histone modifications,
are pivotal in regulating gene expression pathways related to inflammation and cancer …
are pivotal in regulating gene expression pathways related to inflammation and cancer …
Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells
JA Bristol, J Brand, M Ohashi, MR Eichelberg… - PloS …, 2022 - journals.plos.org
Humans are infected with two types of EBV (Type 1 (T1) and Type 2 (T2)) that differ
substantially in their EBNA2 and EBNA 3A/B/C latency proteins and have different …
substantially in their EBNA2 and EBNA 3A/B/C latency proteins and have different …
EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway
Early B cell factor 1 (EBF1) is a transcriptional factor with a variety of roles in cell
differentiation and metabolism. However, the functional roles of EBF1 in tumorigenesis …
differentiation and metabolism. However, the functional roles of EBF1 in tumorigenesis …
Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation
Background CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype,
observed in multiple malignancies and associated with the epigenetic silencing of tumor …
observed in multiple malignancies and associated with the epigenetic silencing of tumor …
CamoTSS: analysis of alternative transcription start sites for cellular phenotypes and regulatory patterns from 5'scRNA-seq data
Five-prime single-cell RNA-seq (scRNA-seq) has been widely employed to profile cellular
transcriptomes, however, its power of analysing transcription start sites (TSS) has not been …
transcriptomes, however, its power of analysing transcription start sites (TSS) has not been …
HOXA5 is a key regulator of class 3 semaphorins expression in the synovium of rheumatoid arthritis patients
S Martínez-Ramos, C Rafael-Vidal… - …, 2023 - academic.oup.com
Objective Class 3 semaphorins are reduced in the synovial tissue of RA patients and these
proteins are involved in the pathogenesis of the disease. The aim of this study was to identify …
proteins are involved in the pathogenesis of the disease. The aim of this study was to identify …
Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer
Background Enhancers are distal cis-regulatory elements required for cell-specific gene
expression and cell fate determination. In cancer, enhancer variation has been proposed as …
expression and cell fate determination. In cancer, enhancer variation has been proposed as …
Super-enhancers: Implications in gastric cancer
Y Huang, Y Huo, L Huang, L Zhang, Y Zheng… - … Research/Reviews in …, 2024 - Elsevier
Gastric cancer (GC) is the fifth most prevalent malignancy and the third leading cause of
cancer-related mortality globally. Despite intensive efforts to enhance the efficiencies of …
cancer-related mortality globally. Despite intensive efforts to enhance the efficiencies of …