Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …

Inappropriate expansion of the adipose cells in the subcutaneous adipose tissue (SAT) is a
characteristic of hypertrophic obesity and of individuals with genetic predisposition for T2D …

Powerful bioinformatics tools have provided a wealth of novel miRNA–transcription factor
networks crucial in controlling gene regulation. In this review, we focus on the biological …

In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a
major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic …

Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic
arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify …

The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has
been widely studied to test candidate leukemia therapies and as a model of cell cycle arrest …

Calcitonin receptor-like (CALCRL) is a G-protein-coupled neuropeptide receptor involved in
the regulation of blood pressure, angiogenesis, cell proliferation, and apoptosis, and is …

Leukemias derived from the MLL-AF9 rearrangement rely on dysfunctional transcriptional
networks. ZNF521, a transcription co-factor implicated in the control of hematopoiesis, has …

Hematopoiesis is a highly complex process, regulated by both intrinsic and extrinsic factors.
Often, these two regulatory arms work in tandem to maintain the steady-state condition of …

Hematopoietic stem cells (HSCs) drive cellular turnover in the hematopoietic system by
balancing self-renewal and differentiation. In the adult bone marrow (BM), these cells are …