Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

Cancer has long been considered a genetic disease characterized by a myriad of mutations
that drive cancer progression. Recent accumulating evidence indicates that the …

Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …

Contrary to conventional wisdom, functional mitochondria are essential for the cancer cell.
Although mutations in mitochondrial genes are common in cancer cells, they do not …

Cancer metabolism has long been equated with aerobic glycolysis, seen by early
biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures …

Heterozygous mutation of IDH1 in cancers modifies IDH1 enzymatic activity, reprogramming
metabolite flux and markedly elevating 2-hydroxyglutarate (2-HG). Here, we found that 2-HG …

Energy metabolism is significantly reprogrammed in many human cancers, and these
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …

Citrate is a critical metabolite required to support both mitochondrial bioenergetics and
cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions …

Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …

The discovery of cancer-associated mutations in genes encoding key metabolic enzymes
has provided a direct link between altered metabolism and cancer. Advances in mass …