Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …

Protein ubiquitination is critical for regulation of numerous eukaryotic cellular processes
such as protein homeostasis, cell cycle progression, immune response, DNA repair, and …

The activity of proteins delivered into host cells by the Dot/Icm injection apparatus allows
Legionella pneumophila to establish a niche called the Legionella-containing vacuole …

Abstract The Legionella pneumophila Sde family of translocated proteins promotes host
tubular endoplasmic reticulum (ER) rearrangements that are tightly linked to phosphoribosyl …

Manipulation of the host's ubiquitin network is emerging as an important strategy for
counteracting and repurposing the posttranslational modification machineries of the host by …

Protein ubiquitination is a multifaceted post-translational modification that controls almost
every process in eukaryotic cells. Recently, the Legionella effector SdeA was reported to …

Microbial pathogens have coevolved with their hosts, often for millions of years, and in the
process have developed a variety of virulence mechanisms to ensure their survival, typically …

The intracellular bacterial pathogen, Legionella pneumophila, establishes the replicative
niche as a result of the actions of a large array of effector proteins delivered via the …

The intracellular bacterial pathogen Legionella pneumophila employs bacteria-derived
effector proteins in a variety of functions to exploit host cellular systems. The ubiquitination …

Ubiquitination regulates many aspects of host immunity and thus is a common target for
infectious agents. Recent studies have revealed that members of the SidE effector family of …